Tea Tree Oil
Highly regarded for its variety of uses, tea tree oil is now used around the world in a vast abundance of cosmetic products. Tea tree oil is a traditional medicine for the aboriginals of Australia, whom used it widely to treat insect bites, skin infections, and even bruising. It has anti-microbial, antifungal, anti-septic, and antiviral properties. Recently, studies have shown that tea tree oil makes for an effective insect repellent, a study on cows that were treated with tea tree oil had 60% less flies on them, 24 hours after treatment, than did the cows without a tea oil treatment.
It has been found that tea tree oil is effective at reducing acne, without harmful side effects. Tea tree oil is used as a dental aid, and indicated as a treatment for arthritis, athletes foot, bladder infections, lice, herpes, warts, and colds.
Please use moderation and care when using herbs and read our disclaimer
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Budhiraja, S. S., Cullum, M. E., Sioutis, S. S., Evangelista, L., & Habanova, S. T. (1999). Biological activity of Melaleuca alternifola (Tea Tree) oil component, terpinen-4-ol, in human myelocytic cell line HL-60. Journal of Manipulative and Physiological Therapeutics, 22(7), 447–453. https://doi.org/10.1016/s0161-4754(99)70033-3
Chandrdas, D., Jayakumar, H. L., Chandra, M., Katodia, L., & Sreedevi, A. (2014). Evaluation of antimicrobial efficacy of garlic, tea tree oil, cetylpyridinium chloride, chlorhexidine, and ultraviolet sanitizing device in the decontamination of toothbrush. Indian Journal of Dentistry, 5(4), 183–189. https://doi.org/10.4103/0975-962X.144718
Klauck, V., Pazinato, R., Stefani, L. M., Santos, R. C., Vaucher, R. A., Baldissera, M. D., Raffin, R., Boligon, A., Athayde, M., Baretta, D., Machado, G., & DA Silva, A. S. (2014). Insecticidal and repellent effects of tea tree and andiroba oils on flies associated with livestock. Medical and Veterinary Entomology, 28 Suppl 1, 33–39. https://doi.org/10.1111/mve.12078
Khalil, Z., Pearce, A. L., Satkunanathan, N., Storer, E., Finlay-Jones, J. J., & Hart, P. H. (2004). Regulation of wheal and flare by tea tree oil: complementary human and rodent studies. The Journal of Investigative Dermatology, 123(4), 683–690. https://doi.org/10.1111/j.0022-202X.2004.23407.x
Malhi, H. K., Tu, J., Riley, T. V., Kumarasinghe, S. P., & Hammer, K. A. (2017). Tea tree oil gel for mild to moderate acne; a 12 week uncontrolled, open-label phase II pilot study. The Australasian Journal of Dermatology, 58(3), 205–210. https://doi.org/10.1111/ajd.12465
Koh, K. J., Pearce, A. L., Marshman, G., Finlay-Jones, J. J., & Hart, P. H. (2002). Tea tree oil reduces histamine-induced skin inflammation. The British Journal of Dermatology, 147(6), 1212–1217. https://doi.org/10.1046/j.1365-2133.2002.05034.x
TEA TREE OIL: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews. (n.d.). Retrieved January 1, 2021, from https://www.webmd.com/vitamins/ai/ingredientmono-113/tea-tree-oil
Satchell, A. C., Saurajen, A., Bell, C., & Barnetson, R. S. (2002). Treatment of dandruff with 5% tea tree oil shampoo. Journal of the American Academy of Dermatology, 47(6), 852–855. https://doi.org/10.1067/mjd.2002.122734
Satchell, A. C., Saurajen, A., Bell, C., & Barnetson, R. S. C. (2002). Treatment of interdigital tinea pedis with 25% and 50% tea tree oil solution: a randomized, placebo-controlled, blinded study. The Australasian Journal of Dermatology, 43(3), 175–178. https://doi.org/10.1046/j.1440-0960.2002.00590.x
Syed, T. A., Qureshi, Z. A., Ali, S. M., Ahmad, S., & Ahmad, S. A. (1999). Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream. Tropical Medicine & International Health: TM & IH, 4(4), 284–287. https://doi.org/10.1046/j.1365-3156.1999.00396.x